Levigation requires geometric dilution.

Levigation requires geometric dilution.

• A. True
• B. False
• C. Not applicable
• D. Sometimes

Answer: (A)

Levigation uses a levigating agent to wet a dry powder and reduce its particle size by forming a smooth paste. After this step, the paste must be incorporated into a larger bulk in a way that keeps the drug evenly distributed. Geometric dilution does exactly this: the paste is blended with diluent in progressively increasing portions so that the drug-to-total-weight ratio remains constant at each step. This approach prevents local concentration differences and ensures a uniform final product, which is especially important for potent drugs given in small amounts. Therefore, levigation typically requires geometric dilution to achieve homogeneity.

Levigation uses a levigating agent to wet a dry powder and reduce its particle size by forming a smooth paste. After this step, the paste must be incorporated into a larger bulk in a way that keeps the drug evenly distributed. Geometric dilution does exactly this: the paste is blended with diluent in progressively increasing portions so that the drug-to-total-weight ratio remains constant at each step. This approach prevents local concentration differences and ensures a uniform final product, which is especially important for potent drugs given in small amounts. Therefore, levigation typically requires geometric dilution to achieve homogeneity.