Levigating agents are chosen based on base type: mineral oil is used for hydrocarbon bases and glycerin for water-removable bases.

Study for the Pharmaceutics II Exam 2 Concepts Test with flashcards and multiple choice questions. Each question has hints and explanations. Prepare effectively for your exam!

Multiple Choice

Levigating agents are chosen based on base type: mineral oil is used for hydrocarbon bases and glycerin for water-removable bases.

Explanation:
The concept being tested is matching the levigating agent to the base type so it aids grinding without dissolving the base. For hydrocarbon (oil-based) bases, the levigating agent should be immiscible with the base to create a separate phase that helps disperse the solid particles—mineral oil fits this role well. For water-removable (hydrophilic) bases, a water-miscible agent like glycerin blends with the aqueous phase, improving wetting and facilitating incorporation into the base. Therefore, mineral oil for hydrocarbon bases and glycerin for water-removable bases is the best pairing. Water would not wet or disperse hydrocarbons well and would disrupt the base; ethanol isn’t the standard levigating agent for water-removable bases in this context. Glycerin for hydrocarbon bases is inappropriate due to poor immiscibility, and using mineral oil for a water-removable base wouldn’t aid wetting. Propylene glycol is sometimes used, but it isn’t universally appropriate for all bases.

The concept being tested is matching the levigating agent to the base type so it aids grinding without dissolving the base. For hydrocarbon (oil-based) bases, the levigating agent should be immiscible with the base to create a separate phase that helps disperse the solid particles—mineral oil fits this role well. For water-removable (hydrophilic) bases, a water-miscible agent like glycerin blends with the aqueous phase, improving wetting and facilitating incorporation into the base. Therefore, mineral oil for hydrocarbon bases and glycerin for water-removable bases is the best pairing.

Water would not wet or disperse hydrocarbons well and would disrupt the base; ethanol isn’t the standard levigating agent for water-removable bases in this context. Glycerin for hydrocarbon bases is inappropriate due to poor immiscibility, and using mineral oil for a water-removable base wouldn’t aid wetting. Propylene glycol is sometimes used, but it isn’t universally appropriate for all bases.

Subscribe

Get the latest from Examzify

You can unsubscribe at any time. Read our privacy policy