Crushing tablets with insoluble excipients will result in which dosage form?

Crushing tablets with insoluble excipients will result in which dosage form?

• A. Suspension
• B. Solution
• C. Emulsion
• D. Gel

Answer: (D)

Crushing a tablet that contains insoluble excipients creates solid drug particles dispersed in a liquid, forming a suspension. The key point is that insoluble components don’t dissolve, so you don’t get a uniform dissolved solution; instead, the solid particles float or settle in the liquid and must be shaken to redisperse. A gel would require a network that traps the liquid, which doesn’t occur simply by crushing a tablet. Likewise, a true solution needs the drug to be soluble, and an emulsion involves two immiscible liquids with droplets, not solid particles in a liquid.

Crushing a tablet that contains insoluble excipients creates solid drug particles dispersed in a liquid, forming a suspension. The key point is that insoluble components don’t dissolve, so you don’t get a uniform dissolved solution; instead, the solid particles float or settle in the liquid and must be shaken to redisperse. A gel would require a network that traps the liquid, which doesn’t occur simply by crushing a tablet. Likewise, a true solution needs the drug to be soluble, and an emulsion involves two immiscible liquids with droplets, not solid particles in a liquid.