Crushed tablets with insolubility considerations yield which dosage form?

Crushed tablets with insolubility considerations yield which dosage form?

• A. Solution
• B. Suspension
• C. Emulsion
• D. Gel

Answer: (B)

Crushed tablets with an insoluble drug are best formulated as a suspension. When a drug isn’t soluble, grinding the tablet into fine particles and dispersing them in a liquid allows a single, uniform dose to be delivered without requiring dissolution. A solution would require the drug to dissolve completely, which isn’t possible here. Emulsions involve mixtures of two immiscible liquids and aren’t the standard approach for a solid drug in a liquid. A gel is a thickened, semi-solid form, which is not the typical choice for delivering incompletely soluble solids as a liquid dosage form.

Crushed tablets with an insoluble drug are best formulated as a suspension. When a drug isn’t soluble, grinding the tablet into fine particles and dispersing them in a liquid allows a single, uniform dose to be delivered without requiring dissolution. A solution would require the drug to dissolve completely, which isn’t possible here. Emulsions involve mixtures of two immiscible liquids and aren’t the standard approach for a solid drug in a liquid. A gel is a thickened, semi-solid form, which is not the typical choice for delivering incompletely soluble solids as a liquid dosage form.